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Major depressive disorder is mostly seen in People between the ages of 45 and 65 are most susceptible to developing major depression. “ Middle-aged individuals are at the peak of the depression bell curve.what is major depressive disorderA serious mental health condition called major depressive disorder (MDD), sometimes referred to as depression or clinical depression, can have a profound impact on a person's day-to-day functioning.Clinical depression, commonly referred to as major depressive disorder (MDD), is a mental illness marked by at least two weeks of persistent melancholy, low self-esteem, and loss of interest or pleasure in typically pleasurable activities.The DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) diagnosis of Major Depressive Disorder is given to those who are depressed and/or have lost interest in formerly loved activities. For a diagnosis to be made, this depressive emotion must be experienced every day for at least two weeks. Adolescence and children may be more agitated than sad. A person may also have low energy, a lack of desire, changes in their weight or sleep patterns, negative thoughts, a loss of attention, and a tendency to avoid activities in addition to having a low or irritated mood.in conclusion, depression is a severe mood disease that has an impact on every aspect of your being, including your thoughts and mood. A chemical imbalance in the brain is the root cause.learn more on Major depressive disorder from/brainly.in/question/17836296#SPJ1