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(beginning/ end) of a gene is the most harmful.
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The most dangerous gene mutation is frameshift.Which mutation is the most harmful?The DNA sequence is most severely damaged by mutations brought on by the insertion or deletion of nitrogenous bases because they entirely alter the reading frame for the process of protein production. The most harmful mutation is thought to be a frameshift mutation caused by an insertion or deletion.Which is worse for you, insertion or substitution?Insertions and deletions typically do more damage than substitutions, which only change one amino acid, since they create a frame-shift that alters the reading of succeeding codons and, consequently, changes the complete set of amino acids that follow the mutation.To know more about mutation visit:-https://brainly.com/question/13923224#SPJ1